KMID : 1130620220180060671
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Journal of Clinical Neurology 2022 Volume.18 No. 6 p.671 ~ p.680
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Correlation Between Neutrophil-to-Lymphocyte Ratio and Motoric Deterioration in Patients With Guillain-Barre Syndrome
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Sutantoyo Felisitas Farica
Fadil Basuki Mudjiani Fidiana Hamdan Muhammad
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Abstract
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Background and Purpose: Guillain-Barre syndrome (GBS) is a common cause of inflammation-related acute flaccid paralysis, and is characterized by acute onset, rapid progression, and symmetrical weakness. GBS is an emergency with high morbidity and long-term disability rates. It is important to determine the prognostic factors for GBS in order to improve the disease outcomes. This study aimed to identify the correlation between the neutrophil-to-lymphocyte ratio (NLR) on day 1 of hospitalization (D1) and motor deterioration in GBS patients.
Methods: This observational analytical study applied a cross-sectional analysis to the medical records of GBS patients who were hospitalized at Dr. Soetomo General Hospital Surabaya from January 2018 to March 2020. The analysis used the chi-square bivariate test, multivariate analysis with logistic regression, and correlation analysis with the Spearman test.
Results: The study included 61 subjects. Statistical tests showed that there was no correlation between NLR and changes in the Medical Research Council sum scores (¥ÄMRC sum scores) during D1?D3, D1?D7, D1?D14, and D1 to the day of discharge (p>0.05). There was a significant correlation between NLR and the Erasmus GBS outcome score (EGOS) (p=0.006). NLR values differed significantly within each treatment group (p=0.001). Therefore, a subanalysis within each treatment group was conducted, which revealed a significant negative correlation (p<0.05) between NLR and the ¥ÄMRC sum score during D1?D14 in the group treated without immunotherapy.
Conclusions: There was no correlation between NLR and motor deterioration in patients with GBS during hospitalization. However, NLR was significantly correlated with EGOS, and there was a negative correlation between NLR and motor deterioration during D1?D14 in GBS patients treated without immunotherapy.
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KEYWORD
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Guillain-Barre syndrome, neutrophil, lymphocyte, clinical deterioration, MRC sum scores
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